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Experimenting with Canine Gastric Carcinoma as a Method Studying the Effects of Anti-cancer Drugs Y. Tanaka 1 , G. Uosumi 1 , H. Inokuchi 1 , A. Aoike 1 , K. Kawai 1 1Department of Preventive Medicine, Kyoto Prefectural University of Medicine pp.745-750
Published Date 1981/7/25
DOI https://doi.org/10.11477/mf.1403108093
  • Abstract
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 As a new experimental model for immunotherapy, dogs administered with ENNG (N-ethyl-N'-nitro-N-nitrosoguanidine) were used to test the effects of anti-cancer drugs. The immuno-potentiator which is the object of study in finding the effects is SPG (schizophyllum polyglucan). Three beagle dogs wherein 12 months had passed after administration of ENNG and having cancerous lesions were used as one group for experimenting therapy. Three dogs administered with ENNG and showing no cancerous lesions after five months were used as another group for experimenting prevention. A total of ten dogs including the two used for control with the group for prevention and another two without ENNG administration were observed endoscopically for eight months.

 For three months after SPG (2mg/kg/week) administration, the change in mitogen response of peripheral lymphocyte by con A and PHA which is T cell mitogen was studied as the immunological parameter.

 As a result, the group administered with SPG maintained the same grade of stimulation index in mitogen response of peripheral lymphocyte as the normal control group. On the contrary, for those without SPG administration, a distinct decrease in mitogen responsecontinued. That is, it was supposed that activation in the T cell function by the SPG was occuring in the SPG‐administered group. However, endoscopical follow-up study indicated that the cancerous lesions of the three dogs in the therapy experiment group advanced and thus no therapeutic effect was the decision. Moreover, in the experiment for prevention, one out of the three dogs indicated cancer but the control group of two dogs without SPG administration showed no apparent cancer lesion. It cannot be stated definitely that this shows preventive effects, but because three is few in number, further investigation is necessary.

 The usefulness of canine gastric cancer as experimental models for testing therapeutic effects of anticancer drugs in early gastric cancer in human beings were studied. Furthermore, follow-up study by endoscopy and also by various immunological parameters were made possible and it was confirmed that the effects of various immuno therapeutic drugs could be investigated.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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