Malignant Schwannoma of the Stomach, Report of a Case with an Emphasis on Immunohistochemical Differential Diagnosis Masaharu Hosoya 1 , Asao Hokama 3 , Kazuhiko Hayashi 2 , Tadaatsu Akagi 2 1The Third Department of Internal Medicine, Okayama University School of Medicine 2The Second Department of Pathology, Okayama University School of Medicine 3Department of Internal Medicine, Konko Hospital Keyword: 胃悪性神経鞘腫 , S-100α蛋白 , S-100β蛋白 pp.457-462
Published Date 1992/4/25
DOI https://doi.org/10.11477/mf.1403106848
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 An 80-year-old female visited our hospital complaining of vomiting of blood. Endoscopic examination and radiography showed a submucosal tumor,5×4.5×3.5 cm in size, in the anterior wall of the angulus. It was classified as Yamada's type Ⅲ. The tumor, protruding into the lumen of the stomach, was elastic firm, well circumscribed and whitish and partly gray on cut surface. Light microscopic examination revealed a densely cellulated tumor consisting mostly of spindle-shaped cells. There were partly pleomorphism and only a few mitoses (Fig.5 c). Electron microscopy showed spindle cells and long-spacing collagen (loose body). Immunohistochemically,S-100 and S-100 α were positive but desmin negative. S-100β was only slightly positive.

 Malignant Schwannoma of the stomach is very rare. It is difficult to differentiate it from leiomyosarcoma not only clinically but pathologically in most cases. Immunohistochemical staining for S-100 α,S-100 β and desmin is useful in histologically differentiating neurogenic sarcoma from myogenic tumors.

Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.


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