Advanced Gastric Cancer with Massive Lymphoid Stroma in von Recklinghausen Neurofibromatosis, Report of a Case Takashi Hayasaka 1 , Yutaka Watanabe 1 , Fumio Ishizaka 1 1Department of Internal Medicine, Hakodate Chu-o Hospital Keyword: von Recklinghausen病 , 胃癌 , lymphoid stroma pp.451-456
Published Date 1992/4/25
DOI https://doi.org/10.11477/mf.1403106846
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 A 53-year-old man with von Recklinghausen neurofibromatosis was admitted to Hakodate Chuo Hospital because of epigastrial discomfort. Laboratory findings revealed hypochromic and microcytic anemia, but negative for fecal occult blood. X-ray and endoscopic examinations revealed Borrmann 2 type advanced gastric carcinoma at the anterior wall of the gastric angle. Histopathological findings showed moderately differentiated tubular adenocarcinoma (pm, INFγ, Vo, Ly3) with massive lymphoid stroma which revealed transluminar proliferation. Massive lymphoid stroma may be due to hyperreactivity of lymphoid tissue against cancer cell in von Recklinghausen neurofibromatosis. This case of von Recklinghausen disease may be caused by mutation, because no relatives had neurofibromatosis. Genetic basis of neurofibromatosis which seems to be related to mutation may have some role in the occurrence of gastric cancer. Neurofibromatosis must be considered as precancerous state in the stomach.

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