Primary Duodenal Tumors and Tumor-like Lesions, Focused on Their Incidence and Brunner's Gland Adenoma. Yoichi Ajioka 1 1The First Department of Pathology, School of Medicine, Niigata University Keyword: 十二指腸腫瘍 , 十二指腸腫瘍様病変 , Brunner腺腺腫 , Brunner腺腺癌 pp.627-638
Published Date 1993/6/25
DOI https://doi.org/10.11477/mf.1403106185
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 We studied on the incidence of primary duodenal tumors and tumor-like lesions excluding tumors of the papilla Vater. The incidence of each type was as follows: heterotopic gastric mucosa and Brunner's gland hyperplasia; 77/103 (74.8%), epithelial neoplasm; 21/103 (20.4%), non-epithelial neoplasm; 5/103 (4.8%). Epithelial neoplasm was composed of adenocarcinoma (11/21,52.4%) and adenoma (8/21,38.1%) and most of non-epithelial neoplasm (4/5,80%) was malignant lymphoma. Most of the lesions in the first portion was tumor-like lesions (63/72,87.5%), but 53.3% of those in the second portion (16/30) was neoplasm which consisted of adenocarcinoma (9/30,30%) and adenoma (4/30,13.3%). Therefore, endoscopists should suspect a lesion in the second portion of the duodenum to be neoplastic.

 We had three cases of Brunner's gland neoplasia examined for histological characteristics and proliferating activity. All of three lesions had histological atypic and higher proliferating activity than normal and hyperplastic Brunner's gland, which were demonstrated by Ki-67 staining. These lesions were thought to be true Brunner's gland adenomas which had not believed to exist. Furthermore, one of them had an area with severe atypia suggesting Brunner's gland carcinoma.

Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.


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