Pathological Study of Differentiated Adenocarcinoma in Fundic Gland Region of the Stomach Tadakazu Shimoda 1 , Mika Matsuoka 1 , Hiroaki Sugisaka 2 , Masahiro Ikegami 2 , Yutaro Egashira 3 1Clinical Laboratory Division, National Cancer Central Hospital 2Department of Pathology I, The Jikei University School of Medicine 3Department of Internal Medicine Ⅱ, Osaka Medical College Keyword: 胃底腺 , 分化型腺癌 , 胃型腺癌 , 腸型腺癌 pp.997-1007
Published Date 1994/9/25
DOI https://doi.org/10.11477/mf.1403105904
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 Nineteen cases (21 lesions) of differentiated adenocarcinoma (DA) in almost normal fundic gland areas were examined by mucinhistochemical methods. The frequency of DA was 0.5% of all gastric carcinomas and 4.1% of carcinomas located in normal fundic gland areas. These DA were distributed in patients of younger age more frequently than in the total number of patients with differentiated-type adenocarcinomas (mean age: 53.2 years old). By mucinhistochemical examination of these DA, 7 lesions of gastric type adenocarcinomas were found. There were 8 lesions of intestinal type and 6 lesions of combined type (gastric and intestinal). There were 13 lesions (62%) of gastric and combined types which manifested gastric phenotypic expression. All the cases of gastric type adenocarcinomas contained gastric foveolar mucin detected when stained galactose oxidase-Schiff. Histology of gastric type adenocarcinomas showed characteristically villous or papillary features. The macroscopic features of these gastric type adenocarcinomas resembled polypoid or submucosal-tumor-like carcinoma which maintained the mucosal pattern without ulceration.

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