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Japanese

The Histological Diagnostic Pitfall of Early Gastric Cancer Tadakazu Shimoda 1 , Yukihiro Nakanishi 2 , Atsushi Saito 2 1Clinical Laboratory Division, National Cancer Center Hospital Keyword: 分化型腺癌 , 未分化型腺癌 , 胃型腺癌 , 腸型腺癌 , 低異型度癌 , 高異型度癌 pp.37-45
Published Date 2000/1/25
DOI https://doi.org/10.11477/mf.1403104625
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 We described adenocarcinoma differentiated type of the stomach can be classified into major two types from the difference of mucin phenotype, one is adenocarcinoma with gastric mucin phenotype and second with intestinal mucin phenotype, and third gastric-intestinal mucin phenotype. The detail histological and biological characters of adenocarcinoma with gastric phenotype is not well known, however, this type of cancer often reveals histologically low grade atypia and is similar to non neoplastic or reactive hyperplastic foveolar epithelium. It is very difficult to make correct histological diagnosis and differential diagnosis between neoplasia and non neoplastic condition. Gross findings of gastric type adenocarcinoma with low grade atypia is polypoid feature with superficial or flat extension in the mucosa (Ⅱb-like) . Biological behabior of gastric type adenocarcinoma transforms to poorly differentiated adenocarcinoma according to larger size of tumor which is over 10 mm in size. On the other hand, pure intestinal type of adenocarcinoma is histologically homologus feature which did not show heterogenous histological feature in the mucosa. We should know the existence of both type adenocarcinoma and these biological behavior.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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