Histological Diagnosis of Serrated Adenoma Yo Kato 1 , Akio Yanagisawa 1 , Kiyoko Kubo 1 , Koichi Koizumi 2 , Carlos A. Rubio 3 1Department of Pathology, Cancer Institute 2Department of Internal Medicine, Cancer Institute Hospital 3Department of Pathology, Karolinska Institute Keyword: serrated adenoma , 組織診断基準 , 化生性ポリープ/過形成ポリープ , villomicroglandular adenoma pp.825-830
Published Date 1998/5/25
DOI https://doi.org/10.11477/mf.1403103718
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 The histological criteria for serrated adenoma (SA) applied at the Cancer Institute is presented. The word“serrated”was originally used to describe changes in the lumen of the gland. We use“serrated”to describe structural changes in the epithelium, because some of the cases are composed of not only glandular structure but also villous structure. In contradistinction to metaplastic polyp/hyperplastic polyp (MP/HP), the generative cells indicated by Ki-67 immunostaining in SA are, though discontinuously, more distributed throughout the lesion. However, in examining the same cases by Kato (Tokyo) and Rubio (Stockholm), it was clarified that there was a small discrepancy in diagnosis of SA between the two; Rubio tended to regard as SA even for some lesions Kato diagnosed as MP/HP (Table 3). Rubio makes much of cellular (or nuclear) atypism. Thus, there seems to be a problem to which level the minimal criteria for SA should be set in differential diagnosis from MP/HP. SAs were side by side often associated with MP/HP and/or tubular or villous adenomas (Table 1, 2). The proviously described villomicroglandular adenoma should be also regarded as serrated adenoma.

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