Japanese

Characteristic Feature of Serrated Adenoma on the Evidence of Ki-67 Positive Cell Pattern Shingo Ishiguro 1 , Masayuki Mano 1 , Tsutomu Kasugai 1 , Katsuhiko Yoshizato 1 1Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases Keyword: serrated adenoma , hyperplastic polyp , tubular adenoma , Ki-67 index histology pp.851-854
Published Date 1998/5/25
DOI https://doi.org/10.11477/mf.1403103724
  • Abstract
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 Histological feature and Ki-67 index of 61 cases of hyperplastic polyps and serrated adenomas were examined.

 We divided Ki-67 positive cell pattern into three types (regenerative type, serrated type and common adenomatous type). The regenerative type is that Ki-67 positive cells were continuously seen from the base of glands to middle part of glands like the non-tumorous regenerative glands, but positive cells were numerous compared with regenerative glands. The serrated type is that Ki-67 positive cells were located in depressive part of serrated epithelium and the positive areas were discontinuous in a tumor gland. The common adenomatous type is that Ki-67 positive cells were continuously seen at almost all cells in the tumor glands.

 All 17 cases of hitologically hyperplastic polyps showed the regenerative type of Ki-67 positive cell pattern.

 Nine cases out of all 22 cases of histologically serrated adenomas showed the serrated type of Ki-67 positive cell pattern, others showed the mixed type.

 All 13 cases of histologically mixed types showed the mixed type of Ki-67 positive cell pattern.

 One histologically tubular adenoma showed adenomatous type of Ki-67 positive cell pattern.

 We concluded the serrated adenoma is a distinct form of neoplasm on the evidence of Ki-67 positive cell pattern.


Copyright © 1998, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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