Colorectal Adenocarcinoma of Common Cell Lineage to Serrated Adenoma: A Special Reference to Its Histologic Features and Cell Differentiation Takashi Yao 1 , Toshio Kouzuki 1 , Masaaki Kajiwara 1 , Ken-ichi Nishiyama 1 , Masazumi Tsuneyoshi 1 1The Second Department of Pathology, Faculty of Medicine, Kyushu University Keyword: serrated adenoma , pS2 , gastric mucin pp.867-872
Published Date 1998/5/25
DOI https://doi.org/10.11477/mf.1403103727
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 The histological features and cell differentiation of carcinomas of the same cell lineage as hyperplastic (metaplastic) polyp (H/MP) or serrated adenoma (SA) were examined. A seventy-year-old woman had a right hemicolectomy. Six carcinomas were recognized in the resected colon. These carcinomas were considered to be of the same cell lineage as the SA and H/MP because of occurrence of multiple SAs and H/MPs as well as the co-existence of SA and H/MP areas in the carcinomas. These carcinomas had common histological and immunohistochemical features as follows, 1) a serrated structure resembling SA, 2) a lace-like structure, 3) infiltrative growth among the muscularis propria with dedifferentiation at the invasive front, 4) immunohistochemical expression of pS2 and human gastric mucin. These findings are useful for detecting carcinomas of the same cell lineage as the SA and H/MP.

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