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Adenosquamous Cell Carcinoma of the Stomach─A Clinicopathologic Analysis of 23 Cases Masahiro Maeda 1 , Hirokazu Taniguchi 1 , Shigeki Sekine 2 , Hitoshi Katai 3 , Ryoji Kushima 1 1Pathology of Clinical Laboratory Division, National Cancer Center Hospital, Tokyo 2Pathology Division of Research Institute, National Cancer Center, Tokyo 3Gastric Surgery Division of Gastrointestinal tumor Department, National Cancer Center Hospital, Tokyo Keyword: 胃腺扁平上皮癌 , 扁平上皮癌 pp.1959-1966
Published Date 2010/11/25
DOI https://doi.org/10.11477/mf.1403102064
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 Twenty-three cases of primary adenosquamous cell carcinoma of the stomach were studied clinicopathologically, including 22 cases(0.14%)out of a total of 15,572 cases with all types of carcinoma of the stomach resected surgically in the last 48 years and 1case resected endoscopically in the National Cancer Research Center Hospital. The average age was 63 with male predominance of 1.6 to 1. The tumors were mostly located at the middle and lower part of the stomach, grossly showing Borrmann type 2or 3 and were 7.4cm in size on average. Almost all of the patients(83%)had lymph node metastases and more than one third of the patients received noncurative resection. These findings indicate the highly malignant potential of adenosquamous cell carcinoma. Five-year-survival rate was about 22% for adenosquamous cell carcinoma, which is worse than that for ordinary adenocarcinomas. Considering pathological and immunohistological findings, adenosquamous cell carcinoma of the stomach probably derives from the squamous metaplasia in adenocarcinoma, and squamous cell carcinoma of the stomach is considered as an extreme type of adenosquamous cell carcinoma.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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