Significance of Phenotypic Expression in Colorectal Epithelial Tumors Takashi Yao 1 1Department of Human Pathology, Juntendo University School of Medicine, Tokyo Keyword: 大腸癌 , 粘液形質 , MUC5AC , MUC2 , CD10 pp.705-709
Published Date 2010/4/30
DOI https://doi.org/10.11477/mf.1403101922
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 Colorectal carcinomas can be classified into colonic type, small intestine type, gastric type, mixed type and unclassified type, according to the combination of expression of three markers ; MUC5AC/HGM for gastric foveolar cells ; the intestinal cup cell MUC2 for intestinal goblet cells and CD10 for the small intestinal brush border. As for the small intestine type, it has high-grade malignancy with high frequency of venous invasion and liver metastasis. As for the colon type, it has relatively low-grade malignancy. As for the mixed type, mucinous carcinoma, villous carcinoma and colitic carcinoma are included. As for gastric type, it is related to serrated carcinoma with prominent infiltrative growth and a tendency of dedifferentiation.

 In addition, phenotypic expression varies according to the difference of histological types(tubular, villous, serrated)in colorectal adenomas. Furthermore, even in the tubular type there is a difference in phenotypic expression between polypoid and non-polypoid types. Non-polypoid tubular adenoma tended to express CD10 and should be attended to as a precursor lesion of CD10 positive carcinoma with high-grade malignancy.

 In this way, the phenotypic expression is closely related to histological features and biological behaviors. It is expected that analysis of phenotypic expression will be applied in future investigation of colorectal carcinomas.

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