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Clinical Application of Molecular Colorectal Carcinogenesis for Gastroenterologists Tamotsu Sugai 1 , Wataru Habano 2 , Kazuyuki Suzuki 3 1Division of Molecular Diagnostic Pathology, Department of Pathology, Iwate Medical University, Morioka, Japan 2Department of Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University, Morioka, Japan 3Department of Surgery, Iwate Medical University, Morioka, Japan Keyword: 大腸癌 , MSI , メチル化 , LOH , micro RNA pp.710-714
Published Date 2010/4/30
DOI https://doi.org/10.11477/mf.1403101923
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 CRC(colorectal cancer)is one of the most frequent cancers in the Western world. CRC development is genetically a multi-step process according to Vogelstein's theory. Four main pathways occur in CRC, including LOH(loss of heterozygosity), MSI(microsatellite instability), epigenetic silencing through the CIMP(CpG island methylator phenotype)and alterations of micro RNA. These pathways have distinct clinical, pathological, and genetic characteristics, which can be used for molecular classification and comprehensive tumor profiling in CRC. Molecular-biological research has advanced with the sequencing of the human genome and the availability of genomic and proteomic high-throughput technologies. This review aims to give an overview of the evolving molecular concepts in CRC and to have potential for clinical implications for gastroenterologists.


Copyright © 2010, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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