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Japanese

Magnifying Narrow Band Imaging may Predict Mucin Phenotype of Early Gastric Carcinomas Masaaki Kobayashi 1 , Satoru Hashimoto 2 , Ken-ichi Mizuno 2 , Manabu Takeuchi 3 , Akito Sato 4 , Rie Azumi 1 , Tomoya Aoyagi 1 , So Kurita 1 , Kazuhiko Shioji 1 , Shunya Sasaki 1 , Rintaro Narisawa 1 , Junji Yokoyama 2 , Shuji Terai 2 1Division of Internal Medicine, Niigata Cancer Center Hospital, Niigata, Japan 2Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 3Division of Gastroenterology, Nagaoka Red Cross Hospital, Nagaoka, Japan 4Division of Gastroenterology, Nagaoka Chuo General Hospital, Nagaoka, Japan Keyword: 早期胃癌 , 粘液形質 , 画像強調内視鏡 , 拡大観察 , H. pylori pp.69-80
Published Date 2018/1/25
DOI https://doi.org/10.11477/mf.1403201262
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 We evaluated 300 samples of early gastric carcinomas detected in 265 patients with confirmed Helicobacter pylori status. NBI-ME(Narrow-band imaging with magnifying endoscopy)findings for early gastric carcinomas were classified into two types based on surface microstructure:papillae and pits. The mucin phenotype and NBI-ME results were significantly correlated(p<0.001). WOS(white opaque substance)and LBC(light blue crest)revealed a high specificity for immunohistologically positive MUC2 and CD10, respectively. However, when we predict mucin phenotype using NBI-ME, the sensitivity and accuracy of the two types of microstructure, WOS, and LBC were not satisfied, especially after H. pylori eradication. We should recognize the limitations of NBI-ME findings in accurately estimating mucin phenotype.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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