Special Stains Useful for Diagnosis of Colon Tumors Akiko Matsubara 1 , Ryoji Kushima 1 , Hirokazu Taniguchi 1 , Shigeki Sekine 2 1Clinical Laboratory Division, National Cancer Center Hospital, Tokyo 2Pathological Division, National Cancer Center Research Institute, Tokyo Keyword: 特殊染色 , 免疫染色 , 大腸腫瘍 , 脈管侵襲 pp.699-704
Published Date 2010/4/30
DOI https://doi.org/10.11477/mf.1403101921
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 Special stains including IHC(immunohistochemical)stains have been applied for the pathological diagnosis of colon tumors. Elastica van Gieson or Victoria Blue-HE stains, and D2-40 IHC are often used to detect venous involvement and lymphatic permeation respectively. Desmin-IHC is used to measure the depth of tumor invasion in the submucosal layer. IHC with Ki67 and p53 proteins is useful for making a differential diagnosis among premalignant lesions, adenocarcinoma and ulcerative-colitis related neoplasms. Phenotyping and evaluating the malignant nature of endocrine tumor, or differentially diagnosing metastatic from primary tumors, IHC is also applied. We pathologists would like to provide more objective and reproducible data using special stains, in addition to routine macroscopic and microscopic studies.

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