Diagnosis of Small Squamous Cell Carcinoma of the Esophagus by Conventional Endoscopic Examination and Chromoendoscopy with Iodine Staining Yuichi Shimizu 1 , Takeshi Yoshida 1 , Mototsugu Kato 2 , Masahira Haneda 1 , Rumiko Asaka 1 , Urara Nishida 1 , Keiko Yamamoto 1 , Aki Imai 1 , Manabu Nakagawa 2 , Shouko Ono 2 , Masahiro Asaka 1 1Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan 2Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan Keyword: 早期食道癌 , 小扁平上皮癌 , 微小食道癌 , 上皮内癌 , HGIN , high grade intraepithelial neoplasia pp.1647-1654
Published Date 2009/10/25
DOI https://doi.org/10.11477/mf.1403101773
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 In this paper, we defined small squamous cell carcinoma of the esophagus as high grade intraepithelial sqamous neoplasia or invasive cancer with a diameter less than 1cm. The important mucosal findings of small squamous cell carcinoma of the esophagus are slight redness, disorder of the minute vessels, slight unevenness and slight whiteness. Especially, slight redness is the most important mucosal finding. The ability to detect small squamous neoplasia of the esophagus can be enhanced considerably by iodine staining during endoscopic examination. Small squamous cell carcinoma will be observed as an iodine unstained area, pink in color. Pink color sign is useful especially in patients with esophageal mucosa showing many minute iodine unstained areas. Because many high grade intraepithelial sqamous neoplasia lesions are considered to develop into invasive cancer, to find small or minute high grade intraepithelial sqamous neoplasia by precise endoscopic examination is clinically important.

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