Leukocytapheresis Therapy of Refractory Ulcerative Colitis Kunio Ohnishi 1 , Takayuki Matsumoto 1 1Division of Lower Gastroenterology, Department of Medicine, Hyogo College of Medicine, Nishinomiya, Japan Keyword: 難治性潰瘍性大腸炎 , 打ち抜き潰瘍 , 血球成分除去療法 , LCAP , GCAP pp.1885-1893
Published Date 2007/12/25
DOI https://doi.org/10.11477/mf.1403101243
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 To make endoscopic findings and leukocytapheresis therapy (CAP) of refractory ulcerative colitis (UC) clear, we made an investigation of severe UC with refractory lesions (punched out ulcer, longitudinal ulcer, pseudopolyposis) in 68 patients (71.6%) who had CAP effective UC and in 27 patients who had undergone colectomy. CAP was efficient for treating patients with acute refractory ulcerative colitis, but was inefficient over a long term period. Endoscopic findings showed there had been little difference between patients who had received CAP and those who had undergone colectomy. The feasibility of CAP for severe ulcerative colitis was estimated from the condition of the mucosa. CT provides an additional noninvasive procedure for determination of disease activity with severe UC. A more appropriate selection of treatment options with CAP in UC needs to be scheduled.

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