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Epstein-Barr Virus-associated Early Gastric Cancer Mimicking Submucosal Tumor, Report of a Case Akira Ohashi 1 , Yasuhiro Sone 2 , Yasuhiro Hisanaga 2 , Takashi Kumada 2 , Keita Sakata 3 1Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine 2Department of Gastroenterology, Ogaki Municipal Hospital 3Department of Pathology, Ogaki Municipal Hospital Keyword: 胃リンパ球浸潤性髄様癌 , 胃粘膜下腫瘍 , EBV関連胃癌 pp.1791-1796
Published Date 2004/12/25
DOI https://doi.org/10.11477/mf.1403100602
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 A 73-year-old female visited our hospital for examination of body weight loss. X-ray and endoscopic examination of the stomach showed a protruded lesion on the anterior wall of the upper gastric body. The lesion looked like a submucosal tumor, and it had an irregular small depression on the top of the protrusion. A biopsy of the lesion demonstrated poorly differentiated adenocarcinoma. Endoscopic ultrasonography revealed a hypoechoic tumor in the second to third layer. Distal gastrectomy was performed. Histological investigation showed a poorly differentiated adenocarcinoma extending to the submucosa with marked infiltration of lymphocytes. This was thought to be a gastric cancer with lymphoid stroma (GCLS). Immunohistological investigation showed that Epstein-Barr virus encoded RNA (EBER)-1 in situ hybridization was positive in the nuclei of the cancer cell, so it was considered to be an Epstein-Barr virus-associated gastric cancer.

 1) Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

 2) Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan

 3) Department of Pathology, Ogaki Municipal Hospital, Ogaki, Japan


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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