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Endoscopic Diagnosis of Epstein-Barr Virus-Associated Gastric Carcinoma Muneaki Miyake 1 , Noriya Uedo 1 , Takashi Kanesaka 1 , Masanori Kitamura 2 , Ryu Ishihara 1 , Koji Higashino 1 , Yoji Takeuchi 1 , Sachiko Yamamoto 1 , Akira Maekawa 1 , Satoki Shichijo 1 , Hiromu Fukuda 1 , Kotaro Waki 1 , Katsunori Matsueda 1 , Takahiro Inoue 1 , Ayaka Tajiri 1 , Tomoki Michida 1 1Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan 2Department of Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan Keyword: EBV関連胃癌 , Epstein-Barr virus , 内視鏡診断 pp.1347-1355
Published Date 2021/9/25
DOI https://doi.org/10.11477/mf.1403202561
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 In recent years, EBV-GC(Epstein-Barr virus-associated gastric carcinoma)has been expected to benefit from immune checkpoint inhibitors due to its molecular biological characterization. EBV-GC has a lower frequency of lymph node metastasis and a better prognosis than common-type gastric carcinoma. EBV-GC accounts for 10% of all cases of gastric cancer, making its detection and diagnosis clinically important. In this study, we retrospectively evaluated the clinicopathological and endoscopic features of 34 lesions in 33 patients with EBV-GCLS(EBV-GC with lymphoid stroma)diagnosed in our hospital. Most lesions were located in the proximal stomach. Superficial cancers were most often type 0-IIc, and advanced cancers were types 2 and 3. Regardless of severity, most lesions had reddish depressed areas and submucosal tumor-like marginal elevations. In 8 patients with narrow-band imaging magnifying endoscopic findings, the micro-surface pattern had both irregular and absent patterns. The main microvessel patterns were fine networks comprising nonuniform polygonal shapes and unclassified vessel pattern characterized by non-tortuous irregular vessels. The histological depth of tumor invasion of superficial cancers was mostly T1b(17/18) ; however, none of the cases had lymph node metastasis in T1b cancers.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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