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The Recent Advances and Concept of Barrett's Esophagus Tadakazu Shimoda 1 1Division of Clinical Laboratory, National Cancer Center Hospital Keyword: Barrett食道 , 食道胃接合部 , 杯細胞化生 , 食道噴門腺 pp.1211-1222
Published Date 2004/8/25
DOI https://doi.org/10.11477/mf.1403100552
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 Although essential for diagnosis of Barrett's esophagus, identification of the esophagogastric junction (EGJ) is extremely difficult. Currently, the best approach to identify EGJ is to determine the lower end of the longitudinal vessels. Barrett's esophagus is a condition in which the normal squamous epithelium of the esophagus is replaced by a columnar epithelium, which exhibits the histological characteristics of the cardiac gland mucosa associated with goblet cell metaplasia and which thus represents the characteristics of the gastric epithelium. The pathogenesis of this disease is still poorly understood, but several mechanisms, such as disdifferentiation from the squamous epithelium, exposure of the esophageal cardiac glands, and differentiation from the multilayered epithelium, have been suggested.

 1) Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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