Japanese

Long-term Follow-up Outcome of Gastric MALT Lymphoma after H. pylori Eradication with Special Reference to t(11 ; 18)(q21 ; q21)Translocation and Endoscopic Ultrasonography Tsuneya Nakamura 1 , Hiroshi Inagaki 2 , Takio Yokoi 3 , Shigeo Nakamura 3 1Department of Gastroenterology, Aichi Cancer Center Hospital 2Department of Pathology, Nagoya City University Medical School 3Department of Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital Keyword: 胃MALTリンパ腫 , EUS , t(11;18)(q21;q21)転座 , API2-MALT1 , H.pylori除菌療法 pp.285-294
Published Date 2004/3/25
DOI https://doi.org/10.11477/mf.1403100439
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 Fifty-seven patients of gastric MALT lymphoma were treated by eradication therapy for Helicobacter pylori and followed up by endoscopy and biopsy. They were classified into 3 groups(Group A,B and C)according to their responsiveness to antibacterial treatment and positivity of t(11 ; 18)(q21 ; q21)translocation, namely API2-MALT1 chimeric transcript(API2-MALT1). Forty-two patients in Group A were responders which showed negative API2-MALT1. Five patients in Group B were non-responders which showed negative API2-MALT1. Ten patients in Group C were non-responders which showed positive API2-MALT1. In group A, characteristics were positive for H. pylori infection, whose tumor invasion was limited in the mucosa or submucosa with clinical stage I. In group B, the characteristics were invasion of the proper muscle or more with clinical stage II1 or more. The component of diffuse large B-cell lymphoma cells and the endoscopic feature of protruded type of tumor were often observed. In group C, the characteristics were negative for H. pylori infection, clinical stage II1 or more, neither diffuse large B-cell lymphoma cells component nor cobblestone mucosa of endoscopic features were present.

 Evaluation of clinical stage by EUS and detection of API2-MALT1 are useful to identify cases that may be responsive to H. pylori eradication therapy.

 1) Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan

 2) Department of Pathology, Nagoya City University Medical School, Nagoya, Japan

 3) Department of Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital, Nagoya, Japan


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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