Long-term Observation and Prognosis of Gastric MALT Lymphomas after H. pylori Eradication Naohiro Dairaku 1 , Katsuaki Kato 1 , Shuichi Ohara 1 , Tooru Shimosegawa 1 1Division of Gastroenterology, Tohoku University Hospital Keyword: , MALT リンパ腫 , H.pylori除菌療法 , 長期経過 , 内視鏡像 pp.277-283
Published Date 2004/3/25
DOI https://doi.org/10.11477/mf.1403100438
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 The present article summarized our long-term observations of gastric MALT lymphomas after H. pylori eradication. Successful eradication of the bacterium brought approximately 90 % of the patients to complete remission(CR)within 1 year after therapy. Endoscopic findings of gastric lesions showed amelioration in the CR cases and turned into localized atrophic areas with discolored appearances ; which features were unchanged during endoscopic following-up for more than 3 years. Histological reconstruction of gastric mucosa affected by the disappearance of lymphoma cells,‘empty lamina propria' was also persistent in these areas. Non-responders to bacterial eradication were associated with the absence of H. pylori infection and the presence of API2-MALT1 chimera gene. Irradiation therapy was a good option for these patients to gain complete remission. However, the cases rejecting additional therapy showed no deterioration in the primary lesions or systemic expansion of the disease during their long-term observation. The strategy for the cure gastric MALT lymphomas still involves quite a few issues to be solved. Further studies are warranted.

 1) Division of Gastroenterology, Tohoku University Hospital, Sendai, Japan

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