The Changes of the Endoscopic, Roentgenographic and Pathological Findings of Gastric MALT Lymphoma after Cure of Helicobacter pylori Infection Tsuneya Nakamura 1 , Shigeo Nakamura 2 , Takashi Suzuki 1 , Takio Yokoi 3 , Akira Matsuura 1 1Department of Gastroenterology, Aichi Cancer Center Hospital 2Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital 3Division of Pathology, Aichi Medical University Hospital Keyword: 胃MALTリンパ腫 , Helicobacter pylori , 除菌療法 , 内視鏡所見 pp.1353-1366
Published Date 1999/10/25
DOI https://doi.org/10.11477/mf.1403102839
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 The relationship between MALT (mucosa-associated lymphoma tissue) lymphomas and Helicobacter pylori (H. pylori) was investigated in 37 patients with special reference to the changes of the endoscopic, roentgenographic and pathological findings of gastric MALT lymphoma after cure of H. pylori infection. Antibacterial treatment consisted of a 1-week course of oral omeprazole, metronidazole and clarithromycin or other regimens. Patients were followed up by means of endoscopy and biopsy. H. pylori was positive in 33 of 37 patients. The overall successful rate of cure of H. pylori infection was 93.9% (31/33). Eleven patients (35.4%) showed complete remission (CR) of lymphoma, 17 (54.8%) partial remission (PR), and three (9.7%) registered no change (NC). Endoscopic appearances of MALT lymphoma were classified into ulcers, erosions, cobblestone appearance, discolored area, lesions like early gastric cancer and polypoid lesions like submucosal tumors. In CR and PR cases, endoscopic appearances changed to atrophic mucosa after cure of H. pylori infection. This atrophic mucosa persisted during the observation period. It could be observed focally in the fundic gland mucosa. Histology showed depletion of tumor cells, atrophic changes of gastric glands and vacant lamina propria. Endoscopy showed a cobblestone appearance only in PR cases and polypoid features predominantly in NC cases.

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