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Endoscopic Treatment for Gastroesophageal Reflux Disese Soji Ozawa 1 , Masashi Yoshida 2 , Koichiro Kumai 3 , Masaki Kitajima 2 1Department of Surgery, School of Medicine, Fujita Health University 2Department of Surgery, School of Medicine, Keio University 3Center for Diagnostic and Theraputic Endoscopy, Keio University Hospital Keyword: 胃食道逆流症 , 内視鏡的治療 , ELGP法 , Stretta法 , Enteryx法 pp.723-729
Published Date 2006/4/24
DOI https://doi.org/10.11477/mf.1403100359
  • Abstract
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 There are six available endoscopic treatments for gastroesophageal reflux disease (GERD). Plicating gastric folds methods, like the EndoCinchTM method (Endoscopic Gastroplication, ELGP method), Full-thickness PlicatorTM method, and Endoscopic Suturing Device (ESD) method, are used to form new plications in the cardia. Alternatively, thermal tissue remodeling/neurolysis methods, like Stretta® System, can be used to denature the muscular layer of the lower esophageal sphincter (LES) region. Finally, bulking injection methods, like Enteryx® Procedure and GatekeeperTM Reflux Repair System, can be used to insert a foreign body into the LES region. All six methods resulted in the improvement of symptoms and acid reflux, but only the bulking injection methods caused an improvement of the manometric findings. The overall discontinuation of the proton-pump inhibitor use has been about 70%. Thus, endoscopic treatments for GERD are still in the developmental phase. Boston Scientific Corporation initiated a voluntary recall of all Enteryx® devices because of safety issues, in September, 2005. It will not be available for a while. The efficacy, safety, durability, cost-effectiveness, and indications must be thoroughly assessed in clinical trials. If the usefulness of endoscopic treatment is confirmed, however, a new minimally invasive treatment strategy for GERD will have been established.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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