Endocrine Cell Carcinoma of the Stomach, Report of a Case Norihiko Kudara 1 , Seishi Orii 1 , Tamotsu Sugai 2 , Torahiko Terui 1 , Masaki Endoh 1 1First Department of Internal Medicine, Iwate Medical University 2Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University Keyword: 胃内分泌細胞癌 , 免疫組織化学染色 , 胃悪性リンパ腫 pp.1059-1066
Published Date 2005/6/25
DOI https://doi.org/10.11477/mf.1403100225
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 A 66-year-old man was admitted to Iwate Medical University hospital with the complaint of tarry stool. A gastric radiography, and an upper gastrointestinal endoscopic examination revealed a huge 2 type tumor in the lesser curvature of the stomach, which extended from the gastric upper body to the antrum. The tumor exhibited a submucosal tumor-like lesion, the gastric wall was well extended. It was difficult to determine from biopsy specimens from the gastric tumor whether the lesion was endocrine cell carcinoma or malignant lymphoma. Immunohistochemical stains led to suspicion of endocrine cell carcinoma. For this reason, total gastrectomy was performed. Histopathological findings showed homogeneous proliferation of neoplastic cells with a high N/C ratio and a fine chromatic nucleus, but adenocarcinoma was not observed. The neoplastic cells had invaded to the serosal layer and the metastatic lesion was diagnosed as confined to the D1 lymph node. Immunohistochemical stains showed the neoplastic cells had strong immunoreactivity with antibodies against Grimelius, NSE, NCAM and chromogranin A. This led us to a diagnosis of endocrine cell carcinoma of the stomach. In this paper, we reported the characteristics of images and histopathological findings of gastric endocrine cell carcinoma in this case. Gastric endocrine cell carcinoma has a characteristic of rapid growth and progression, and the prognosis is very poor. We cocluded that immunohistochemical stains were useful for diagnosis of gastric endocrine cell carcinoma.

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