菌状息肉症に続発した皮膚アミロイドーシス

・菌状息肉症に皮膚アミロイドーシスが続発した症例を経験した．

・臨床的にポイキロデルマ，乾癬様，結節など多彩な皮膚所見を認めた．

・真皮に沈着したアミロイドは抗ケラチン染色が陽性であり，皮膚アミロイドーシスと診断した．

・ナローバンドUVB（NBUVB）療法で紅斑の消褪傾向と結節部の平坦化がみられ，効果的であった．

（「症例のポイント」より）

　

Secondary cutaneous amyloidosis in a patient with mycosis fungoides

　

Tsukahara, Rieko1）Umemoto, Naoka1）Yamada Tomoko2）Kawase, Masaaki2）Demitsu, Toshio2） 1）Department of Dermatology, Sashiogi Hospital 2）Department of Dermatology, Jichi Medical University Saitama Medical Center

　

A 53-year-old woman had received topical steroid for her eruption as atopic dermatitis for 20 years. She had had diffuse poikiloderma on the trunk and extremities. A nodule on the knee and well-delineated erythematous plaque with a silvery-white scale on her buttocks and her thigh also existed. A biopsy specimen revealed an atypical lymphocyte infiltration from the epidermis to the dermis and necrosis of the keratinocytes. In addition, amorphous eosinophilic deposits were present in the papillary dermis. We diagnosed this case as secondary cutaneous amyloidosis associated with mycosis fungoides.