緩徐な増大傾向を認めた肺アミロイドーシスの2例

Two cases of pulmonary amyloidosis with interval growth

アミロイドーシスでは，線維状の異常蛋白質が肺胞壁および血管などの間質組織，消化管粘膜，腎尿管間質などに徐々に沈着していく。臨床症状は血管の脆弱性亢進による出血，紫斑，末梢神経障害，手根管症候群，認知症，うっ血性心不全，腎障害，消化管吸収不良，骨関節痛などで，肺では無症状のケースも多いが，胸痛，呼吸困難，喀血をきたすこともある。今回，我々は石灰化結節影を呈し増大過程をフォローできた肺アミロイドーシスの2症例を経験したので報告する。

We experienced 2 cases of multiple nodular pulmonary amyloidosis（AL type）in which an interval growth of their size and calcification were observed. The margin was slightly irregular, and calcification gradually progressed, and lung metastasis of mucinous adenocarcinoma etc. were supposed in the differentiation, making preoperative diagnosis difficult. Although pulmonary amyloidosis is a very rare disease, it should be kept in mind as one of the differential diagnoses of multiple pulmonary nodules showing gradual growth. The common findings in the HRCT are lobulated contour, irregular calcification, and multiplicity with different size.