驅虫剤（四塩化エチレン、四塩化炭素、チモール）に因る—聽器障碍の3例に就て

　驅虫剤の服用後におこる聽器障碍は中毒性の聽神経炎をおこすためであるとされ，Oppikoffer，Jankhoff以来多くの人々によつて臨床的にも実験的にも其の障碍が内耳乃至蝸牛神経幹のものであることが確定されている。我が国に於ても，ヘノポヂ油，アスカリドール，ネマトール，チモール等の名で夫々中毒症例が記載され其の数は30例に垂んとしている。

　近年四塩化炭素，四塩化エチレンが驅虫剤として使用せらるに及び，其の中毒による聽器障碍例も見られるに至つたが其の報告例は非常に尠い。我々は最近四塩化エチレン及び四塩化炭素，チモールの併用使用の後に起つた聽器障碍の3例を経過したので茲に報告し，諸賢の御参考に供する次第である。

TAKAFUJI and associates report 3 cases of hearing impairment that was caused by toxic ef-fects of tetrachlorethylene, carbontetrachloride and thymol, when they had been used either in combination or alone, for treatment of anchylo-stomiasis and ascariasis. In the first and second case history revealed familial tendency toward deafness; with the third case, carbotetrachlori-de and thymol were administered simultaneously over and above patient's poor physical conditions which were noted at the beginning of treatment with generalized weakness; to the second and third case the antihelmintic drugs were given da-ily for the period of 7 days. In all cases the amount of medication administered was conside-red as an overdosage. The authors believe that this toxicity was manifested in the inner ear and cochlear nerve; marked loss of hearing was elicited in the middle and high tones. The pati-ents did not improve under parenteral use of pi-locarpin and vitamin B₁.