脳腫瘍血管透過性の超微形態—第2報 グリオーマにおけるCE効果

Ultrastructure of Capillary Permeability in Human Brain Tumors: Part 2: Mechanisms of contrast enhancement in gliomas

I．はじめに

　computed tomography（CT）上，脳腫瘍におけるcontrast enhancement（CE）の機序に関する解明は十分とはいえない．グリオーマにおけるCE効果は，多少の例外はあるとしても，medulloblastoma, ependy—moma, glioblastoma, astrocytomaの順である．そこでこれら4種の腫瘍血管の超微形態を超薄切片法と凍結割断レプリカ法を用いて検索し，4種におけるCE効果の相違を，血管透過性の面から比較検討した．

In order to elucidate the mechanism of contrast enhancement on computerized tomography (CT), the alteration of capillary permeability was studied in 3 cases of medulloblastoma, 2 cases of ependymoma, 5 cases of glioblastoma and 5 cases of astrocytoma. The surgical specimens were studied with con-ventional ultrathin section and freeze-fracture replica techniques.

Contrast enhancement on CT scan defined in order of medulloblastoma, ependymoma, glioblastoma and astrocytoma.

In the medulloblastomas and glioblastomas, the cell junctions of the capillaries were short, elongated, and, in fact open.