パーフェナジンの脳波及びMinor Tremorの周波数分布に及ぼす影響

STUDY OF THE EFFECTS OF PERPHENAZINE UPON EEG AND MINOR TREMOR IN SHIZOPHRENICS BY MEANS OF AUTOMATIC FREQUENCY ANALYSER

　精神分裂病患者18例に，パーフェナジン1日量30mg　5日間，40mg　5日間使用し，使用前と使用10日目に脳波（全例）及びMT（10例）を測定し，脳波及びMTの周波数分布の変化を追求し症状の変化及び副作用との関係を検討した。

　1）脳波周波数に与える影響には一定の関係は認め得ず，また，全例平均ではほとんど変化を認めなかつたが，α優勢の普通にみられる周波数分布のpatternよりはずれたものは，正常人にみられるpatternになるか，あるいはこれに近づいて来る傾向を認めた。

　2）脳波周波数分布と症状の変化及び副作用との間には特記すべき関係はみいだし得なかつた。

　3）MTに及ぼす影響は，一般にθ帯の増加が著しく，β帯も増加し，α帯の減少を認めた。

　4）MT周波数分布と症状の変化との関係については，好転をきたしたものにはαの増加がみられた。またθ増加のものもやや好転と認められるものが多かつた。θ，α，β各帯域と副作用の関係はみいだせなかつたが，パーキンソン様症状の甚しいものには，β₂出現率増加の著明なものがあつた。

Perphenazine was given orally to 18 schi-zophrenic patients at the dosage of 30 mg/ daily, initially for 5 days and thereafter 40 mg/daily. The EEG, in all cases, and the MT, in 10 cases, were recorded before and 10 days after the onset of medication of perphenazine and the results of their fre-quency analyses were studied in this report.

1) The mean values of the frequency dis-tribution of EEG were not significantly al-tered by the administration of perphenazine. However the atypical pattern of the frequen-cy distribution before medication tended to become normal.

2) The frequency spectra of EEG were neither related to therapeutic effects nor side-effects.

3) With respect to the effects upon the MT, it was generally found that the appear-ance of band θ was remarkably increased, that of band β was increased and the band a was decreased.

4) In the clinically improved cases, the increase of band α in MT was found. The θ increased cases showed slight improvement clinically. The frequency distribution of the MT was not related to side-effects. However, remarkable increase of β₂ was seen in cases with Parkinsonoid.