精神科領城におけるLévomépromazineの使用経験

THERAPEUTIC USE OF LEVOMEPROMAZINE IN PSYCHIATRY

　1）ヒルナミンを躁病，うつ病，精神分裂病の17例に投与し，うつ病6例中4例に情動性不安苦悶の解除を認めたが，躁病1例に就ては余り鎮静的効果が得られなかつた。分裂病10例に就ては5例に有効で特に情動性興奮を主とする症例には有効であつたが自閉無為の著しい症例ではかえつて症状の悪化を認めた。

　2）本剤は主として生命的な深い身体感情の抑うつや苦悶に基く症例に有効で分裂病に於ても先ず患者の情動面に作用するものに考えられ，他のフェノチアジン系薬物と異つた新しい鎖静効果を有し，他剤の効果が乏しい場合にも効果を期待し得る。しかし神経症性又ヒステリー色彩の強い抑うつや人格障害の強い患者には余り著しい効果が認められない。

　3）本剤の有効量はクロールプロマジンの¹／₂〜¹／₃で足りるため治療初期には疲労感，睡気が認められる事もあるが，比較的早く消失しその他の重篤な副作用は比較的少い。

　4）以上の点からヒルナミンは可成り強力な情動安定作用を有し，殊に苦悶，情動性不安を伴う種々の抑うつ状態に極めて有効な薬剤であると考える。

The therapeutic efficacy of Levomeproma-zine, a derivative of the phenothiazine has been studies by the authors in certain psy-chiatric diseases, namely, 10 cases of schizo-phrenia, 6 cases of melancholia and a mania. The results were summarized as follows:

1. The drug was effective in 4 out of 6 cases of melancholia and such symptoms as emotional anxiety and agitation appear to be relieved. In mixed type, a case which showed manic excitement exhibited no marked sedative effect. In schizophrenias, the drug was effective 6 out of 10 cases particularly so in those fresh cases which showed emo-tional excitement whereas in chronic type in which autism and abulia were pronounced tend to make symptoms worse.

2. The foregoing results seem to indicate that the drug is most effective in those cas-es of which symptoms were chiefly associa-ted with severe depression of bodily sensa-tion and agitation, and posessed of different sedative effect unlike the other phenothia-zine drugs. On the other hand, it showed less effect on neurotic depression or hysteri. cal melancholia.