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Manual Tracing Guideline for Volumetry of Hippocampus and Amygdala with High-Resolution MRI Yutaka Matsuoka 1,2,3 , Etsuro Mori 4,6 , Masatoshi Inagaki 2,3 , Yukiko Kozaki 2 , Tomohito Nakano 5 , Marcus Wenner 2 , Yosuke Uchitomi 2 1Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurologyand Psychiatry 2Psycho-Oncology Division, National Cancer Center Research Institute East 3Ex-awardees of a Research Resident Fellowship from the Foundation for Promotion of Cancer Research in japan 4Hyogo Institute for Aging Brain and Cognitive Disorders, current affiliation 5Psychiatry Division, National Cancer Center Hospital 6Department of Humanities and Sciences, Kobe Gakuin University Keyword: MRI volumetry , hippocampus , amygdala , manual tracing pp.690-697
Published Date 2003/8/1
DOI https://doi.org/10.11477/mf.1406100525

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  • Abstract
  • Look Inside

Both the hippocampus and amygdala are frequently targeted by researchers and clinicians for volumetric analysis based on magnetic resonance imaging(MRI). However, different data acquisition, analysis software and anatomical boundaries have in the past made it difficult to compare results of MRI studies from different laboratories. A reliable original segmentation protocol for volumetry of the amygdala and hippocampus on three-dimensional MRI was established by including merits of previous volumetric studies. Two skilled raters measured randomly selected 20 subjects from 242 subjects recently scanned in our institution(mean age 47.6±6.1 years). Data acquisition was performed with a three-dimensional spoiled gradient echo technique. Volumetric analysis was performed manually using three-dimensional software that allowed coronal, sagittal, and transverse images at any time. Both intra- and inter-rater reliability(intraclass correlation coefficients)yielded 0.99 for the hippocampus and 0.98 for the amygdala. It was confirmed that this segmentation protocol was highly reliable.


Copyright © 2003, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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