Helicobacter pylori除菌後の胃潰瘍再発

Peptic Ulcer Recurrence with Successful Eradication of Helicobacter pylori

要旨　胃潰瘍症例においてH. pyloriの除菌が再発防止に有用であるかどうかを282例を用いて5年間追跡し検討した．221例は除菌を目的に治療を受けており，61例は通常の内科的治療を受けた．除菌に成功．した53例で再発をみたのはわずか3例のみであった．除菌に不成功であった168例中154例で再発をみとめ，H. pyloriを行わなかった61例の再発56例と同様の再発の頻度であった，以上より，胃潰瘍症例においてH. pylori除菌は再発防止に有用である．

　To evaluate the recurrence rate of gastric ulcer after eradication of H. pylori, 282 gastric ulcer patients were followed-up over a period of five years.

　221patients were given therapy aimed at the eradication of H. pylori. 61 patients received acid-reducing conventional therapy.

　Six months after termination of treatment, it was found that 53 patients were conpletely free of H. pylori. During the next five years, three out of these 53 H. pylori-cured patients showed a relapse of gastric ulcer even though there was no reinfection with H. pylori.

　H. pylori eradication was unsuccessful in 168 cases and relapse of gastric ulcers was observed in 154 of these cases. Gastric ulcers also relapsed in 56 of the 61 patients that hadn't received H. pylori eradication treatment.

　It can safely be concluded that absence of H. pylori or successful H. pylori eradication prevents relapse in gastric ulcer patients.