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Chronological Trends of Gastric Carcinoma from the Pathological View Point in Special Reference to Helicobacter pylori Infection Ken Nishikura 1 , Yoichi Ajioka 2 , Gen Watanabe 2 , Takashi Kato 2 , Takehiko Enomoto 2,3 1Division of Molecular and Functional Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 2Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 3Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Keyword: 胃癌 , 時代的変遷 , 組織型 , 形質 , Helicobacter pylori pp.921-930
Published Date 2007/5/25
DOI https://doi.org/10.11477/mf.1403101109

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 The aim of this study was to clarify the chronological trends of pathological findings of gastric carcinoma. We analysed 14,608 lesions from 11,908 cases of gastric carcinoma, which were surgically resected from 1979 through 2006 in Nigata University Hospital and its related institutes. It was revealed that : 1) There was a decreasing number of gastric carcinoma cases especially among younger patients, 2) There was a relatively increasing number of differentiated-dominant type carcinoma, and 3) There was a relatively increasing number of intestinal-dominant phenotype cases. It was additionally demonstrated through analysis of 524 lesions from 480 cases of small gastric carcinoma : 1) There was no significant difference in H. pylori-positive rate according to histological type, and 2) Carcinoma of gastric-dominant phenotype showed significantly a higher H. pylori-positive rate and a significantly lower intestinal-metaplasia index on surrounding mucosa compared with intestinal-dominant phenotype.


Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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