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Japanese

Differentiated Gastric Adenocarcinoma with Gastric Phenotype: Its New Classification and Histopathological Characteristics Ken Nishikura 1 , Hidenobu Watanabe 1 , Yoichi Ajioka 1 1The First Department of Pathology, Niigata University School of Medicine Keyword: 分化型胃癌 , 細胞形質 , 異型度 , 組織型 , E-cadherin , Helicobacter pylori pp.495-506
Published Date 1999/3/25
DOI https://doi.org/10.11477/mf.1403103005
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 The aim of this study was to establish a new classifications for cellular phenotype of differentiated gastric adenocarcinoma and to clarify the pathological characteristics of gastric phenotype carcinoma. In 351 cases, the ratio of gastric phenotype carcinoma was 17.4% (61/351) : foveolar phenotype 7.7% (27/351) and pyloric mucosal phenotype 9.7% (34/351). There was a significantly higher rate of undifferentiation among gastric phenotype carcinomas than among intestinal phenotype carcinomas (32.3% vs 7.9%, p < 0.01). Also, the incidence rate of mutant E-cadherin was significantly higher among gastric phenotype carcinomas than among intestinal phenotype carcinomas (19.4% vs 2.7%, p < 0.01). It was observed that mutant E-cadherin-positive cells were distributed continuously from the proliferative zone of the differentiated carcinoma glands to undifferentiated carcinoma parts in eight of ten mucosal carcinomas. Central parts of the tumors were constituted of proper gastric mucosal elements in all 21 differentiated gastric microcarcinomas with gastric phenotype. As for microcarcinoma with low-grade atypia, Helicobacter pylori was directly attached to 40.0% (2/5) of microcarcinomas with gastric phenotype, 30.0% (6/20) of those with compound phenotype, and 9.7% (3/31) of those with incomplete intestinal phenotype. As for microcarcinomas with high-grade atypia, there was no lesion with direct attachment to H.pylori.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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