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Pathological Characteristics of Differentiated-type Early Gastric Carcinoma Mixed with Undifferentiated-type―Status of Lymph Node Metastasis and Macroscopic Features Gen Watanabe 1 , Yoichi Ajioka 1 , Takashi Kato 1 , Ken Nishikura 2 1Division of Molecular and Diagnostic Pathology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan 2Division of Molecular and Functional Pathology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan Keyword: 胃癌 , 組織型 , リンパ節転移 , 内視鏡的治療 , 肉眼的特徴 pp.1577-1587
Published Date 2007/10/25
DOI https://doi.org/10.11477/mf.1403101208

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 Histological type of 780 surgically resected single M and SM1 gastric carcinoma was classified into 4 subtypes; pure differentiated-type (PD), mixture of differentiated and undifferentiated-type (differentiated-type predominant; MD, undifferentiated-type predominant; MU), and pure undifferentiated type (PU), and the status of lymph node metastasis was investigated. Metastatic rate of M carcinoma was 1.6% (11/679) and those of PD, MD, MU, PU were 0% (0/405), 1.6% (1/63), 11.8% (6/51), and 2.5% (4/160), respectively. Metastatic rate of SM1 carcinoma was 3.0% (3/101). Their intramucosal component was MD (1/3) and MU (2/3), and their submucosal component was PD (2/3) and MU (1/3). Judging by these results, it was thought that differentiated-type M and SM1 gastric carcinoma containing the undifferentiated-type component has a risk of lymph node metastasis and that the risk of MU is higher than that of MD. Furthermore, it was suggested that MU has a higher metastatic potential than that of PU. Macroscopic type and features were investigated for 1,974 M and SM1 gastric carcinomas regardless of the co-existence of other gastric carcinoma. The major macroscopic type of both MD and MU was type IIc (more than 70%in frequency), and more than 40%of type IIc or IIb with size greater than 50 mm was shared by MD and MU. The macroscopic feature of MD and MU was that that of a lesion consisted of co-existence of area with typical macroscopic findings of PD and PU, or that the whole lesion consists of admixture of the macroscopic findings of PD and PU.


Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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