無疹部の皮膚生検が診断の一助となった全身性アミロイドーシス

・腹部の無疹部より皮膚生検し，病理組織学的所見でアミロイドの沈着を認め，全身性アミロイドーシスの確定診断の一助となった．

・皮膚生検は他臓器の生検と比べ侵襲が少なく，容易であり，アミロイドーシスの診断に積極的に取り入れるべきと考える．

（「症例のポイント」より）

　

A case of systemic amyloidosis that diagnosis was aided by a biopsy from the normal skin

　

Kamei, Chisato1）Tohda, Rie1）Shimizu, Nami1）Okabayashi, Aya1）Nakagawa, Koichi1） 1）Department of Dermatology, Saiseikai Tondabayashi Hospital

　

An 80-year-old male diagnosed with lower edema and diarrhea was admitted to　the department of cardiovascular internal medicine in our hospital. As doctors detected full circumferential wall thickening by an echocardiogram, they suspected the patient was suffering from cardiac amyloidosis. Therefore, they requested us to perform a skin biopsy on the abdomen without abnormal eruption. Histopathology of the specimen revealed an amyloid deposit around the blood vessels in the adipose tissue. These findings aided the diagnosis of systemic amyloidosis. We emphasized such a skin biopsy is very safe and useful for the diagnosis of systemic amyloidosis.