ヒトヘルペスウイルス6Bをウイルス分離培養で同定した薬剤性過敏症症候群

・薬剤性過敏症症候群（drug-induced hypersensitivity syndrome：DIHS）は再燃しやすく遅発性臓器障害も問題となるため，確実に診断することが望ましい．

・しかし臨床的にDIHSを強く疑っても，ヒトヘルペスウイルス6（human herpesvirus：HHV-6）を同定することができずDIHSの診断にまで至らないことも少なくない．

・HHV-6Bの再活性化をウイルス分離培養で同定し，DIHSを早期に診断した1例を経験した．

（「症例のポイント」より）

　

A case of drug-induced hypersensitivity syndrome with positive reactivity of human herpesvirus 6B by using virus isolation culture inspection

　

Usuda, Chiho1）Kobayashi, Tsukane2）Nagai, Akiyo2）Yoshikawa, Tetsushi3）Sugiura, Kazumitsu2） 1）Department of Dermatology, Fujita Health University Bantane Hospital 2）Department of Dermatology, Fujita Health University School of Medicine 3）Department of Pediatrics, Fujita Health University School of Medicine

　

Abstract A 47-year-old woman who had a persistent high fever, systemic erythema, and face edema after having taken Carbamazepine for one month. The number of atypical lymphocyte was elevated and her liver functions were deteriorating. The clinical symptoms were not reversible with discontinuation of the drug. We finally diagnosed Drug-induced Hypersensitivity Syndrome (DIHS)with positive reactivity of Human herpesvirus 6B by using virus isolation culture inspection.