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Bone and calcium metabolism associated with malignancy. Treatment of radium-223 dichloride for bone metastasis in castration resistant prostate cancer patients. Uemura Hiroji 1 1Department of Urology and Renal Transplantation, Yokohama City University Medical Center, Japan. pp.1485-1493
Published Date 2018/10/28
DOI https://doi.org/10.20837/42018111485
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 In patients with castration resistant prostate cancer(CRPC), the most frequent site of metastases is bone particularly with osteoblastic change, which accounts for 90% at the late stage of CRPC and is accompanied by symptomatic skeletal symptoms(SSEs)such as bone pain or pathological fractures. Radium-223(Ra-223)dichloride emits α particles and has been proven to improve overall survival(OS)and QOL by reducing SSEs in metastatic CRPC patients. Although hemotoxic adverse events(AEs)of Ra-223 treatment including anemia, neutropenia and thrombocytopenia, and non-hemotoxic AEs including nausea, diarrhea and bone pain have been reported, they were mild and well tolerated. The completion of 6 injections of Ra-223 is important for prolonging OS. The optimal time of Ra-223 administration is recommended the duration when PSA is increasing regardless of abiraterone or enzalutamide treatment prior to chemotherapy.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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