腎不全患者の骨質異常の本態は何か？

Treatment of Bone Diseases in ESRD Patients. Several factors related with bone quality abnormalities exist in patients with renal failure.

　末期腎不全患者の骨病変は，様々な骨質異常を含んでいることが少しずつ明らかになっている。この骨質異常は腎不全患者の骨折リスク要因として理解されているが，その実態の全容は掴めていない。またこの異常を惹起する要因についても明確でない。本稿では末期腎不全患者でみられる骨質異常とその誘発要因を紹介し，骨質異常の本態について考察する。

　Recently, several papers revealed that bone pathophysiological abnormalities related with end-stage renal disease（ESRD）contain a multiplicity of injured bone quality. Although deteriorated bone quality in ESRD patients is understood as a risk factor of fracture in these patients, actual conditions still remain unclear. 　Here, I will provide a short review on both the deteriorated bone quality in ESRD patients and animal models, and also specific conditions which is providing abnormality. I also will discuss the problem points of abnormal bone quality in ESRD patients.