Bone and Cartilage Diseases and Regeneration. The clinical condition and therapy of bone diseases. Miura Kohji 1 , Oznono Keiichi 2 1Department of pediatrics, Osaka Graduate School of Medicine, Japan. 2Department of pediatrics, Osaka Graduate School of Medicine, Japan. pp.1789-1794
Published Date 2013/11/28
DOI https://doi.org/10.20837/4201312097
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 Skeletal dysplasia is the term which represents disorders including growth and differentiation of bone, cartilage and ligament. A lot of diseases are included, and new disorders have been added. However, the therapy of most bone diseases is less well-established. Achondroplasia, hypochondroplasia, and osteogenesis imperfecta are most frequent bone diseases. There is no curative treatment for these diseases, however, supportive therapies are available;for example, growth-hormone therapy for achondroplasia and hypochondroplasia, and bisphosphonate therapy for osteogenesis imperfecta. In addition, enzyme replacement therapy for hypophosphatasia is now on clinical trial.


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