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Role of Androgen in the Elderly. The role of androgen on metabolic parameters. Fukui Michiaki 1 , HiroshiOkada 2 , Nakamura Naoto 3 1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan. 2Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan. 3Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan. pp.1125-1132
Published Date 2013/7/28
DOI https://doi.org/10.20837/4201308037
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 Low concentrations of endogenous androgens have been linked with insulin resistance, which is an important upstream driver for metabolic abnormalities such as hyperglycemia, dyslipidemia or hypertension. Androgen deprivation therapy is associated with an increased incidence of diabetes and cardiovascular disease. On the other hand, administration of testosterone to hypogonadal men improved insulin sensitivity and glucose homeostasis.  Men with diabetes have been reported to have lower serum testosterone concentrations than non-diabetic men, which lead to insulin resistance, depression, cognitive dysfunction, sexual dysfunction and cardiovascular disease. Further basic and clinical studies investigating the role for androgen on metabolic parameters and atherosclerosis are needed.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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