Volume 26, Issue 7 (June 2016)
Japanese

Osteoporosis in Men. Dehydroepiandrosterone(DHEA)and bone metabolism. Ohnaka Keizo 1 1Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Japan. pp.987-993
Published Date 2016/6/28
DOI https://doi.org/10.20837/4201607023
  • Abstract
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 Dehydroepiandrosterone(DHEA), an adrenal androgen, has attracted much attention as an anti-aging hormone as well as a marker for senescence because of its unique change along with aging. DHEA is reported to have beneficial effects such as anti-diabetes, anti-obesity, and anti-atherosclerosis. It is also shown that DHEA has anti-osteoporosis effects to increase bone mineral density in randomized controlled trials(RCTs). As osteoblasts express aromatase which will convert androgen to estrogen, DHEA may act protectively against osteoporosis through its metabolites. Because there is no report on fracture risk by DHEA administration, further studies are required to clarify DHEA effects on human bone metabolism.



基本情報

09175857.26.7.jpg
CLINICAL CALCIUM
26巻7号 (2016年6月)
電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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