薬物療法と皮質骨微細構造の変化

Bone Structural Properties and Bone Strength. Effect of anti-osteoporotic agents on cortical microstructure.

　高齢者になると非椎体骨折の発生頻度が増加するが，それには皮質骨微細構造の変化が一因と考えられる。骨折リスクを増大させる皮質骨微細構造の加齢変化と骨強度との関係，またビスホスホネート，テリパラチド，活性型ビタミンD3，デノスマブの骨粗鬆症治療薬が皮質骨微細構造へ作用する効果について考える。

　The incidence of non-vertebral fracture increases in old age, and the deterioration of cortical micro-structure is considered to be one of important reason to cause non-vertebral fracture. In this chapter, the age-related change of cortical microstructure, relationship with bone strength are discussed as well as the effect of anti-osteoporotic drugs on cortical bone；bisphosphonate, teriparatide, active vitamin D3, and denosumab.