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Functional Network between Bone and Organs. Rheumatoid arthritis and bone -periarticular and systemic bone loss-. Ono Kumiko 1 , Ohashi Satoru 2 , Tanaka Sakae 3 1Department of Orthopaedic Surgery, The University of Tokyo Hospital, Japan. 2Department of Orthopaedic Surgery, The University of Tokyo Hospital, Japan. 3Department of Orthopaedic Surgery, The University of Tokyo Hospital, Japan. pp.249-255
Published Date 2013/1/28
DOI https://doi.org/10.20837/4201302097
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 In rheumatoid arthritis(RA),the osteoclast pathway is activated by an abnormal immune condition accompanied by chronic inflammation, resulting in periarticular osteoporosis and local bone destruction around joints. In addition, multiple factors including pharmacotherapies such as steroids, and reduced physical activity, lead to systemic osteoporosis. These conditions expose patients to increased fracture risk. In RA treatment, it is important to achieve suppression of fracture risk by controlling inflammation, which is associated with periarticular osteoporosis and bone destruction, using disease-modifying anti-rheumatic drugs or biologic agents and by improving systemic osteoporosis using anti-osteoporotic agents.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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