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要旨
無症候性高クレアチンキナーゼ血症を有する患者が全身麻酔終了後に悪性高熱症様の症状を発症し,ダントロレンが奏効し救命できた。悪性高熱症関連遺伝子検査を施行したが既報の関連遺伝子には変異を認めず,悪性高熱症素因は確定できなかった。
Female patient with asymptomatic hypercreatinekinasemia underwent paranasal sinus surgery under general anesthesia. Immediately after the discontinuation of the inhalational anesthetic agent, she developed tachypnea, tachycardia, and impaired consciousness, accompanied by a rapid increase in body temperature to 39.1℃. An arterial blood gas analysis revealed acidosis. Postoperative malignant hyperthermia was suspected and immediate treatment was initiated, including an intravenous administration of dantrolene, re-intubation, high-flow oxygen, and external cooling. Her condition improved rapidly, and she was successfully extubated the following day. Next-generation panel sequencing for malignant hyperthermia(MH)did not reveal any pathogenic variations in the known causative MH genes.

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