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神経内分泌腫瘍(neuroendocrine tumors:NETs)は,体内の神経内分泌細胞から発生する比較的まれな腫瘍群である。これらの腫瘍は,ホルモンや神経活性物質を産生する能力を特徴とし,多様な臨床症状と生物学的挙動を示す1)。NETsの中でも,高悪性度神経内分泌腫瘍(high-grade neuroendocrine tumors:HGNETs)は特に攻撃的な性質をもち,予後不良な悪性新生物群として知られている2)。
Neuroendocrine tumors(NETs)are a relatively rare group of tumors that arise from neuroendocrine cells in the body, produce hormones and neuroactive substances, and exhibit diverse clinical symptoms and biological behaviors. Among NETs, high-grade neuroendocrine tumors(HGNETs)are known to be a group of malignant neoplasms with particularly aggressive properties and poor prognosis. In this article, we provide a comprehensive overview of the epidemiology, pathological characteristics, genetic characteristics, and imaging findings of NETs in the thoracic region, and in the second half, we focus on the latest molecular biological findings, advances in imaging diagnostic techniques, and the possibility of personalized treatment using large language models.
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