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Utility of bone scintigraphy and 18F-FDG PET/CT in early detection and risk assessment of medication-related osteonecrosis of the jaw Satoru Watanabe 1 1Department of Nuclear Medicine Kanazawa University Hospital Keyword: 顎骨壊死 , 骨シンチグラフィ , FDG-PET pp.1093-1097
Published Date 2018/10/10
DOI https://doi.org/10.18888/rp.0000000577
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Medication-related osteonecrosis of the jaw(MRONJ)is a significant side effect of antiresorptive and antiangiogenic drugs. Since MRONJ is intractable, early detection is the best way to limit progression. Bone scintigraphy and 18F-fluorodeoxyglucose positron-emission tomography can detect minimal and subclinical changes in bones earlier than conventional radiological modalities. A differential diagnosis including MRONJ is recommended when we detect abnormally high uptakes in the jaws of patients who have bone metastases. Quantitative analysis of uptakes, such as bone scan index of the jaw(BSIJ)using neural network analysis, could differentiate MRONJ from common dental diseases and be useful for the early detection and risk assessment of MRONJ.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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