顆粒球コロニー刺激因子産生悪性胸膜中皮腫

Malignant Pleural Mesothelioma with High Serum Granulocyte Coronary Stimulating Factor

悪性胸膜中皮腫は比較的まれな疾患であるが，近年増加傾向にある1）．一方，顆粒球コロニー刺激因子（G-CSF）は腫瘍細胞から産生されることがあり，G-CSF産生腫瘍として肺癌症例での報告が散見される2）．われわれは，白血球増多を示し血清G-CSFが高値であった悪性胸膜中皮腫の1例を経験したので，報告する．

A 38-year-old man was admitted to our hospital because of right chest pain and high fever. Chest X-ray and computed tomography scan revealed right pleural effusion and pleural thickness. Diagnosis of malignant mesothelioma was established by pleural biopsy. Serum level of granulocyte colony stimulating factor （G-CSF） was high. We performed extrapleural pneumonectomy which improved high fever and inflammation, however the patient died three months after surgery.