顆粒球コロニー刺激因子（G-CSF）産生膀胱癌

Granulocyte Colony-stimulating Factor (G-CSF) Producing Bladder Carcinoma:A Case Report

　73歳，男性。肉眼的血尿を主訴に受診した。膀胱に径8cmの腫瘍を認めた。入院時末梢血白血球数は16,700／mm³，血清G-CSF濃度は149pg／mlと高値を示した。膀胱全摘除術後，白血球数および血清G-CSF濃度は正常化した。本症例は，G-CSF産生膀胱癌としては本邦20例目であると思われた。

A 73-year old male presented with gross hematuria. The laboratory studies revealed remarkable leukocytosis of 16,700/mm³ (neutrophils, 83%) in the peripheral blood. Serum analysis revealed a high level of granulocyte colony-stimulating factor (G-CSF), 149 pg/ml. Cystoscopy, CT and MRI demonstrated a large bladder tumor. The patient underwent total cystectomy and construction of ileal conduit. Histological diagnosis was undifferentiated carci-noma. After surgery, WBC count in the peripheral blood and serum G-CSF concentration decreased within normal range. This is the 20th reported case of G-CSF producting bladder tumor in Japan.