癌化学療法による副作用と選択的要因との関係

The Relationship Between Selected Variables and Side Effects Experienced by Cancer Patients Receiving Chemotherapy

要旨

　癌化学療法患者が経験する副作用は，広範囲にわたり，その程度にも差がある。化学療法だけでこの違いを説明することは不可能であり，他の要因を検討しなければならない。

　本研究の目的は，化学療法による副作用と抗癌剤，患者の疾患に対する認知，不安，ヘルスローカスオブコントロールとの関係を明らかにすることである。対象は，がんセンターに入院し，化学療法を受けた患者87名である。これらの対象者に，副作用に対する独立変数の影響を調べるための質問紙に記入を求めた。

　分析の結果，化学療法の副作用には，受けた化学療法の回数，疾患に対する認知，不安と有意な正の相関が見られた。化学療法の回数が多く，病気の否定的認知が高く，不安が高い程，副作用を経験していた。しかし，副作用と抗癌剤数，ヘルスローカスオブコントロールとの有意な関係はみられなかった。

Abstract

　Cancer patients receiving similar chemotherapy regimens experience wide variations in side effects. Chemotherapy alone, can not explain these variations. Therefore, other variables should be considered to determine their importance in the incidence of side effects.

　The purpose of this study was to examine the relationship of severity of side effects of chemotherapy regimens, patient's perception of disease, anxiety, and health locus of control. Subjects were 87 patients with a confirmed diagnosis of cancer who were receiving chemotherapy hospitalized in a cencer center. Each subject completed instruments designed to measure the effects of the independent variables on severity of side effects of chemotherapy.

　The results of analysis of data showed that severity of side effects was significantly correlated with the number of chemotherapy cycles received, patient's perception of disease, and anxiety. Those individuals, with many cycles of chemotherapy, a very negative perception of disease, and higher state and trait anxiety, experienced more severity of side effects. However, severity of side effects was not significantly correlated with the number of chemotherapeutic agents and health locus of control.